Darmstadt, Germany, February 3, 2012 – Merck KGaA today announced that a global agreement was signed with Threshold Pharmaceuticals, Inc., South San Francisco, to co-develop and commercialize TH-302, Threshold’s small molecule hypoxia-targeted drug. TH-302 is currently being investigated in a global Phase III clinical trial in patients with soft tissue sarcoma, a randomized Phase II trial in patients with advanced pancreatic cancer from which top-line results are expected in February, as well as additional clinical studies in other solid tumors and hematological malignancies.

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Darmstadt / London, January 30, 2012 – Merck KGaA announced today that in cooperation with the World Health Organization (WHO) it wants to eliminate the tropical worm disease schistosomiasis in Africa. The major offensive in this effort is Merck’s commitment to a tenfold increase, from 25 million to 250 million, of its annual donation of praziquantel tablets, the most effective treatment for the parasitic worm disease schistosomiasis.

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“The Merck Group produced solid third-quarter revenue growth in a difficult environment, driven mainly by good performances from the Merck Serono and Merck Millipore divisions. Net profit rose by 8% on higher revenues and as one-time costs from last year were not repeated, leaving us well positioned as we head into the end of the year,” said Dr. Karl-Ludwig Kley, Chairman of the Executive Board of Merck KGaA. “We are making progress in driving our change agenda forward and we will provide important updates on this endeavor in the first half of 2012.”

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